ZHOU Cheng, LI Zhanhong, WANG Xinghao, LIU Shuyuan, WANG Zifeng, XUE Liang, ZHU Zhigang
(School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)
Abstract: A fentanyl electrochemical sensor based on ionic liquid [BMIM]PF6-reduced graphene oxide/silver dendrite composite modified screen-printed electrode ([BMIM]PF6-rGO/Ag/SPE) was developed to realize the rapid detection of fentanyl with a low limit of detection, high sensitivity and high selectivity. The hydrophobic ionic liquid [BMIM]PF6 was used to preconcentrate fentanyl in the active region of the electrode. The response of the [BMIM]PF6-rGO/Ag/SPE with optimized electrodeposition parameters is 2.0–100.0 μmol/L by fentanyl square wave voltammetry, with a limit of detection of 0.87 μmol/L. The [BMIM]PF 6-r GO/Ag/SPE sensor exhibited excellent reproducibility with RSD of 4.88%, while the sensor's sensitivity is about 5 times higher than that of the unmodified screen-printed electrode. Moreover, the sensor does not need complex electrode pretreatment before detection. The whole detection process took less than 1 min, which perfectly meets the actual needs of fast and convenient drug detection.
Key words: ionic liquid; reduced graphene oxide; Ag dendrite; screen-printed electrode; fentanyl