MAI Jinling ^{1, 2}, WANG Chen ^{1, 2}, HUANG Baoyue ^{1, 2}, XU Liangge ³, ZHANG Litu ^{1, 2}
(1. Oncology Medical College, Guangxi Medical University, Nanning 530021, Guangxi, China; 2. Guangxi Cancer Molecular Medicine Engineering Research Center, Nanning 530021, Guangxi, China; 3. National Key Laboratory of Science and Technology on Advanced Composites in Special Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China)

Abstract: To optimize the luminescence properties and enhance their fluorescence imaging capabilities, YOF::Yb^3+,Er³⁺nanoparticles, with YOF as the matrix and:Yb^3+,Er³⁺ as dopants, were synthesized by using co-precipitation process. The preparation process to have samples with pure color and high fluorescence emission intensity was screened through orthogonal experiment according to the chromaticity analysis results. As revealed by TEM images, micromorphologies of the YOF:Yb^3+,Er³⁺ nanoparticles were between circle and honeycomb shape, with an average size of about 50 nm. After 980 nm laser exposure, the fluorescence emission had a relatively high ratio of red/green. The optimal conditions included water bath temperature of 85 ℃, calcination time of 1 h and KF content of 1 mol, leading to sample with properties meeting the requirements of red fluorescence contrast agent.

Key words: YOF; fluorescence; co-precipitation process; orthogonal experiment; radiography